![]() ![]() Amyloid fibrils as building blocks for natural and artificial functional materials. Protein-based functional nanomaterial design for bioengineering applications. Self-assembled bionanostructures: proteins following the lead of DNA nanostructures. Designed aromatic homo-dipeptides: formation of ordered nanostructures and potential nanotechnological applications. A possible role for π-stacking in the self-assembly of amyloid fibrils. Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology. Peptide and protein building blocks for synthetic biology: from programming biomolecules to self-organized biomolecular systems. Self-assembly in nature: using the principles of nature to create complex nanobiomaterials. Self-complementary oligopeptide matrices support mammalian cell attachment. ![]() Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane. From the globular to the fibrous state: protein structure and structural conversion in amyloid formation. Self-assembly of peptide nanotubes and amyloid-like structures by charged-termini-capped diphenylalanine peptide analogues. Prions: protein aggregation and infectious diseases. A theory of linear and helical aggregations of macromolecules. From macroscopic measurements to microscopic mechanisms of protein aggregation. Nanomechanics of functional and pathological amyloid materials. Cross-link-governed dynamics of biopolymer networks. ![]() Mechanical properties of the cytoskeleton and cells. Steering cell migration: lamellipodium dynamics and the regulation of directional persistence. The role of the cytoskeleton and molecular motors in endosomal dynamics. Fabrication of novel biomaterials through molecular self-assembly. Perspectives in supramolecular chemistry - from molecular recognition towards molecular information processing and self-organization. Self-assembly in natural and unnatural systems. As our fundamental understanding of peptide self-assembly evolves, increasingly sophisticated materials and applications emerge and lead to the development of a new set of building blocks and assembly principles relevant to materials science, molecular biology, nanotechnology and precision medicine. In particular, we explore how naturally occurring structures and phenomena have inspired the development of functional biomimetic materials that we can harness for potential interactions with biological systems. In this Review, we discuss recent conceptual and experimental advances in self-assembling artificial peptidic materials. The self-assembly of synthetic biomimetic peptides thus allows the exploration of chemical and sequence space beyond that used routinely by biology. The assembly of these structures commonly involves interactions between specific molecular building blocks, a strategy that can also be replicated in an artificial setting to prepare functional materials. Natural biomolecular systems have evolved to form a rich variety of supramolecular materials and machinery fundamental to cellular function. ![]()
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